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'Genesis 2000' DNA Sequencer, England, 1988

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The Institute of Food Research investigated the protein engineering cycle. It wanted to examine the structure/function relationships in enzymes such as papain. This sequencer (seen on the left) together with the DuPont Coder 300 DNA Synthesiser was used in the investigation. The ‘Genesis 2000’ used the analytical approach developed at MIT by Walter Gilbert. It was commercialised by large chemical company DuPont. The effects of site-specific mutations were predicted using the synthesiser. They were verified in a cloned specimen using the sequencer.

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Glossary: DNA

DNA stores the information, or blueprints, of every cell and is located in the genes. It is made up of two strands which form a double helix that is linked by hydrogen bonds. It was first described in 1953 by Francis Crick and James Watson.

Glossary: biochemistry

The study of the chemical processes and substances which occur in living organisms.

Glossary: enzyme

One of a group of complex organic substances formed in the living cells of plants and animals. A catalyst for the chemical reactions of biological processes.

Glossary: protein sequencer

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