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Laboratory notebook, 'Mouse Book, Factor IX', United Kingdom, 1980-1985

Labelled “Mouse Book, Factor IX”, this laboratory notebook details experiments by Edward Tuddenham, Frances Rotblat and Donogh O’Brien at the Clinical Research Centre, Northwick Park, which is to the north of London. This work led to the development of a monoclonal antibody to Factor IX. Monoclonal antibodies are identical antibodies cloned from a single cell. Factor IX is one of the factors involved in blood clotting. Its absence causes a type of haemophilia, treatable using Factor IX from human blood plasma. It is shown here with an open laboratory notebook on purification of Factor VIII (1994-1204). The work of Professor Tuddenham led to the development by the Genentech corporation of Factor VIII which was produced by bacteria rather than humans.

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Related Themes and Topics



Glossary: antibody

Molecules produced by the body which attach themselves to the micro-organisms that cause disease and destroy them.

Glossary: bacteria

Micro-organisms which can cause disease but have an important role in global ecology.

Glossary: haemophilia

A hereditary disease in which the blood clots very slowly, causing prolonged bleeding following any injury.

Glossary: laboratory notes

No description.

Glossary: clotting factors

Chemicals in the blood which interact to make the blood clot.